학술논문
HBV continuum of care using community- and hospital-based screening interventions in Senegal: Results from the PROLIFICA programme
Document Type
article
Author
Amina Sow; Maud Lemoine; Papa Souleymane Toure; Madoky Diop; Gora Lo; Jean De Veiga; Omar Thiaw Pape; Khady Seck; Gibril Ndow; Lamin Bojang; Arame Kane; Marina Oudiane; Jess Howell; Shevanthi Nayagam; Jude Moutchia; Isabelle Chemin; Maimuna Mendy; Coumba Toure-Kane; Mark Thursz; Mourtalla Ka; Yusuke Shimakawa; Souleymane Mboup
Source
JHEP Reports, Vol 4, Iss 10, Pp 100533- (2022)
Subject
Language
English
ISSN
2589-5559
Abstract
Background & Aims: Strategies to implement HBV screening and treatment are critical to achieve HBV elimination but have been inadequately evaluated in sub-Saharan Africa (sSA). Methods: We assessed the feasibility of screen-and-treat interventions in 3 real-world settings (community, workplace, and hospital) in Senegal. Adult participants were screened using a rapid HBsAg point-of-care test. The proportion linked to care, the proportion who had complete clinical staging (alanine transaminase [ALT], viral load, and FibroScan®), and the proportion eligible for treatment were compared among the 3 intervention groups. Results: In 2013–2016, a total of 3,665 individuals were screened for HBsAg in the community (n = 2,153) and in workplaces (n = 1,512); 199/2,153 (9.2%) and 167/1,512 (11%) were HBsAg-positive in the community and workplaces, respectively. In the hospital setting (outpatient clinics), 638 HBsAg-positive participants were enrolled in the study. All infected participants were treatment naïve. Linkage to care was similar among community-based (69.9%), workplace-based (69.5%), and hospital-based interventions (72.6%, p = 0.617). Of HBV-infected participants successfully linked to care, full clinical staging was obtained in 47.5% (66/139), 59.5% (69/116), and 71.1% (329/463) from the community, workplaces, and hospitals, respectively (p