학술논문
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
Document Type
article
Author
Pradeep Natarajan; Akhil Pampana; Sarah E. Graham; Sanni E. Ruotsalainen; James A. Perry; Paul S. de Vries; Jai G. Broome; James P. Pirruccello; Michael C. Honigberg; Krishna Aragam; Brooke Wolford; Jennifer A. Brody; Lucinda Antonacci-Fulton; Moscati Arden; Stella Aslibekyan; Themistocles L. Assimes; Christie M. Ballantyne; Lawrence F. Bielak; Joshua C. Bis; Brian E. Cade; Ron Do; Harsha Doddapaneni; Leslie S. Emery; Yi-Jen Hung; Marguerite R. Irvin; Alyna T. Khan; Leslie Lange; Jiwon Lee; Rozenn N. Lemaitre; Lisa W. Martin; Ginger Metcalf; May E. Montasser; Jee-Young Moon; Donna Muzny; Jeffrey R. O’Connell; Nicholette D. Palmer; Juan M. Peralta; Patricia A. Peyser; Adrienne M. Stilp; Michael Tsai; Fei Fei Wang; Daniel E. Weeks; Lisa R. Yanek; James G. Wilson; Goncalo Abecasis; Donna K. Arnett; Lewis C. Becker; John Blangero; Eric Boerwinkle; Donald W. Bowden; Yi-Cheng Chang; Yii-Der I. Chen; Won Jung Choi; Adolfo Correa; Joanne E. Curran; Mark J. Daly; Susan K. Dutcher; Patrick T. Ellinor; Myriam Fornage; Barry I. Freedman; Stacey Gabriel; Soren Germer; Richard A. Gibbs; Jiang He; Kristian Hveem; Gail P. Jarvik; Robert C. Kaplan; Sharon L. R. Kardia; Eimear Kenny; Ryan W. Kim; Charles Kooperberg; Cathy C. Laurie; Seonwook Lee; Don M. Lloyd-Jones; Ruth J. F. Loos; Steven A. Lubitz; Rasika A. Mathias; Karine A. Viaud Martinez; Stephen T. McGarvey; Braxton D. Mitchell; Deborah A. Nickerson; Kari E. North; Aarno Palotie; Cheol Joo Park; Bruce M. Psaty; D. C. Rao; Susan Redline; Alexander P. Reiner; Daekwan Seo; Jeong-Sun Seo; Albert V. Smith; Russell P. Tracy; Ramachandran S. Vasan; Sekar Kathiresan; L. Adrienne Cupples; Jerome I. Rotter; Alanna C. Morrison; Stephen S. Rich; Samuli Ripatti; Cristen Willer; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; FinnGen; Gina M. Peloso
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.