학술논문
Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies
Document Type
article
Author
Lorenzo Piermatteo; Stefano D’Anna; Ada Bertoli; Maria Bellocchi; Luca Carioti; Lavinia Fabeni; Mohammad Alkhatib; Simone La Frazia; Miriam Lichtner; Claudio Mastroianni; Giuseppe De Sanctis; Massimo Marignani; Caterina Pasquazzi; Nerio Iapadre; Giustino Parruti; Giuseppina Cappiello; Jacopo Vecchiet; Vincenzo Malagnino; Sandro Grelli; Francesca Ceccherini-Silbertein; Massimo Andreoni; Loredana Sarmati; Valentina Svicher; Romina Salpini
Source
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
Subject
Language
English
ISSN
22221751
2222-1751
2222-1751
Abstract
ABSTRACTSpecific HBsAg mutations are known to hamper HBsAg recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape mutations from 2005 to 2019 and their correlation with virological parameters in a large cohort of patients infected with HBV genotype-D (N = 947), dominant in Europe. Overall, 17.7% of patients harbours ≥1 vaccine-escape mutation with the highest prevalence in subgenotype-D3. Notably, complex profiles (characterized by ≥2 vaccine-escape mutations) are revealed in 3.1% of patients with a prevalence rising from 0.4% in 2005–2009 to 3.0% in 2010–2014 and 5.1% in 2015–2019 (P = 0.007) (OR[95%CI]:11.04[1.42–85.58], P = 0.02, by multivariable-analysis). The presence of complex profiles correlates with lower HBsAg-levels (median[IQR]:40[0–2905]IU/mL for complex profiles vs 2078[115–6037]IU/ml and 1881[410–7622]IU/mL for single or no vaccine-escape mutation [P