학술논문
Management of anticoagulation in atrial fibrillation patients in Italy: insight from the Atrial Fibrillation-Survey on Anticoagulated Patients Register (AF-START)
Document Type
article
Author
Daniela Poli; Walter Ageno; Emilia Antonucci; Salvatore Bradamante; Eugenio Bucherini; Paolo Chiarugi; Antonio Chistolini; Benilde Cosmi; Anna Falanga; Antonio Insana; Domenico Lione; Rosa Maria Lombardi; Giuseppe Malcangi; Rossella Marcucci; Giuliana Martini; Lucilla Masciocco; Carmelo Paparo; Daniele Pastori; Simona Pedrini; Vittorio Pengo; Pasquale Pignatelli; Andrea Toma; Sophie Testa; Gualtiero Palareti
Source
Bleeding, Thrombosis and Vascular Biology, Vol 2, Iss 2 (2023)
Subject
Language
English
ISSN
2785-5309
Abstract
The survey on anticoagulated patients register (START-Register) is an independent, prospective, inception-cohort observational study aimed at providing information on patients on vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) in Italy. In this study, we describe the cohort of atrial fibrillation (AF) patients in the START-Register and report outcomes and changes in anticoagulant prescription from 2011 to 2021. The study included 11,078 AF patients, enrolled in 47 Italian centers distributed all over the Country; the median age was 77 years (range 18-99 years); 6029 (54.3%) were men; 5135 (46.4%) were on VKAs, and 5943 (53.6%) were on DOACs. Warfarin was the most prescribed VKA (98.4%), and apixaban was the most prescribed DOAC (31.6%). Among DOAC users, 4022 (67.7%) patients were naive to anticoagulation, and 2562 (43.1%) patients were treated with a reduced dose. DOAC patients were significantly older than VKA patients (median age 79 years vs 76 years respectively, P