학술논문
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics
Document Type
article
Author
Helen E. Speedy; Renée Beekman; Vicente Chapaprieta; Giulia Orlando; Philip J. Law; David Martín-García; Jesús Gutiérrez-Abril; Daniel Catovsky; Sílvia Beà; Guillem Clot; Montserrat Puiggròs; David Torrents; Xose S. Puente; James M. Allan; Carlos López-Otín; Elias Campo; Richard S. Houlston; José I. Martín-Subero
Source
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show active chromatin and target genes in the risk loci.