학술논문
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Document Type
article
Author
Philip J. Law; Maria Timofeeva; Ceres Fernandez-Rozadilla; Peter Broderick; James Studd; Juan Fernandez-Tajes; Susan Farrington; Victoria Svinti; Claire Palles; Giulia Orlando; Amit Sud; Amy Holroyd; Steven Penegar; Evropi Theodoratou; Peter Vaughan-Shaw; Harry Campbell; Lina Zgaga; Caroline Hayward; Archie Campbell; Sarah Harris; Ian J. Deary; John Starr; Laura Gatcombe; Maria Pinna; Sarah Briggs; Lynn Martin; Emma Jaeger; Archana Sharma-Oates; James East; Simon Leedham; Roland Arnold; Elaine Johnstone; Haitao Wang; David Kerr; Rachel Kerr; Tim Maughan; Richard Kaplan; Nada Al-Tassan; Kimmo Palin; Ulrika A. Hänninen; Tatiana Cajuso; Tomas Tanskanen; Johanna Kondelin; Eevi Kaasinen; Antti-Pekka Sarin; Johan G. Eriksson; Harri Rissanen; Paul Knekt; Eero Pukkala; Pekka Jousilahti; Veikko Salomaa; Samuli Ripatti; Aarno Palotie; Laura Renkonen-Sinisalo; Anna Lepistö; Jan Böhm; Jukka-Pekka Mecklin; Daniel D. Buchanan; Aung-Ko Win; John Hopper; Mark E. Jenkins; Noralane M. Lindor; Polly A. Newcomb; Steven Gallinger; David Duggan; Graham Casey; Per Hoffmann; Markus M. Nöthen; Karl-Heinz Jöckel; Douglas F. Easton; Paul D. P. Pharoah; Julian Peto; Federico Canzian; Anthony Swerdlow; Rosalind A. Eeles; Zsofia Kote-Jarai; Kenneth Muir; Nora Pashayan; The PRACTICAL consortium; Andrea Harkin; Karen Allan; John McQueen; James Paul; Timothy Iveson; Mark Saunders; Katja Butterbach; Jenny Chang-Claude; Michael Hoffmeister; Hermann Brenner; Iva Kirac; Petar Matošević; Philipp Hofer; Stefanie Brezina; Andrea Gsur; Jeremy P. Cheadle; Lauri A. Aaltonen; Ian Tomlinson; Richard S. Houlston; Malcolm G. Dunlop
Source
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17 new risk SNPs at previously reported loci.