학술논문
Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
Document Type
article
Author
Chiara Chiavelli; Malvina Prapa; Giulia Rovesti; Marco Silingardi; Giovanni Neri; Giuseppe Pugliese; Lucia Trudu; Massimiliano Dall’Ora; Giulia Golinelli; Giulia Grisendi; Jonathan Vinet; Marco Bestagno; Carlotta Spano; Roberto Vito Papapietro; Roberta Depenni; Katia Di Emidio; Anna Pasetto; Daniela Nascimento Silva; Alberto Feletti; Silvia Berlucchi; Corrado Iaccarino; Giacomo Pavesi; Massimo Dominici
Source
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Subject
Language
English
ISSN
2397-768X
Abstract
Abstract Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising the development of autologous CAR T cell therapies. We here generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of GBM primary cells. We detected a robust antitumor effect, highlighting the feasibility of developing an autologous anti-GD2 CAR T cell-based therapy for GBM patients.