학술논문
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
Document Type
article
Author
Marco Medici; Eleonora Porcu; Giorgio Pistis; Alexander Teumer; Suzanne J Brown; Richard A Jensen; Rajesh Rawal; Greet L Roef; Theo S Plantinga; Sita H Vermeulen; Jari Lahti; Matthew J Simmonds; Lise Lotte N Husemoen; Rachel M Freathy; Beverley M Shields; Diana Pietzner; Rebecca Nagy; Linda Broer; Layal Chaker; Tim I M Korevaar; Maria Grazia Plia; Cinzia Sala; Uwe Völker; J Brent Richards; Fred C Sweep; Christian Gieger; Tanguy Corre; Eero Kajantie; Betina Thuesen; Youri E Taes; W Edward Visser; Andrew T Hattersley; Jürgen Kratzsch; Alexander Hamilton; Wei Li; Georg Homuth; Monia Lobina; Stefano Mariotti; Nicole Soranzo; Massimiliano Cocca; Matthias Nauck; Christin Spielhagen; Alec Ross; Alice Arnold; Martijn van de Bunt; Sandya Liyanarachchi; Margit Heier; Hans Jörgen Grabe; Corrado Masciullo; Tessel E Galesloot; Ee M Lim; Eva Reischl; Peter J Leedman; Sandra Lai; Alessandro Delitala; Alexandra P Bremner; David I W Philips; John P Beilby; Antonella Mulas; Matteo Vocale; Goncalo Abecasis; Tom Forsen; Alan James; Elisabeth Widen; Jennie Hui; Holger Prokisch; Ernst E Rietzschel; Aarno Palotie; Peter Feddema; Stephen J Fletcher; Katharina Schramm; Jerome I Rotter; Alexander Kluttig; Dörte Radke; Michela Traglia; Gabriela L Surdulescu; Huiling He; Jayne A Franklyn; Daniel Tiller; Bijay Vaidya; Tim de Meyer; Torben Jørgensen; Johan G Eriksson; Peter C O'Leary; Eric Wichmann; Ad R Hermus; Bruce M Psaty; Till Ittermann; Albert Hofman; Emanuele Bosi; David Schlessinger; Henri Wallaschofski; Nicola Pirastu; Yurii S Aulchenko; Albert de la Chapelle; Romana T Netea-Maier; Stephen C L Gough; Henriette Meyer Zu Schwabedissen; Timothy M Frayling; Jean-Marc Kaufman; Allan Linneberg; Katri Räikkönen; Johannes W A Smit; Lambertus A Kiemeney; Fernando Rivadeneira; André G Uitterlinden; John P Walsh; Christa Meisinger; Martin den Heijer; Theo J Visser; Timothy D Spector; Scott G Wilson; Henry Völzke; Anne Cappola; Daniela Toniolo; Serena Sanna; Silvia Naitza; Robin P Peeters
Source
PLoS Genetics, Vol 10, Iss 2, p e1004123 (2014)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P