학술논문
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas
Document Type
article
Author
Source
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
Genomic structural variants (SVs) in cancer are notoriously difficult to identify, despite the impact they have on cancer progression and treatment efficacy. This study applies state-of-the-art computational methods to catalogue SVs in 383 cases of oesophageal cancer, uncovering mutational patterns and new disease drivers.