학술논문
Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)Research in context
Document Type
article
Author
Rhea Harewood; Joseph A. Rothwell; Jelena Bešević; Vivian Viallon; David Achaintre; Audrey Gicquiau; Sabina Rinaldi; Roland Wedekind; Cornelia Prehn; Jerzy Adamski; Julie A. Schmidt; Inarie Jacobs; Anne Tjønneland; Anja Olsen; Gianluca Severi; Rudolf Kaaks; Verena Katzke; Matthias B. Schulze; Marcela Prada; Giovanna Masala; Claudia Agnoli; Salvatore Panico; Carlotta Sacerdote; Paula Gabriela Jakszyn; Maria-Jose Sánchez; Jesús Castilla; María-Dolores Chirlaque; Amaia Aizpurua Atxega; Bethany van Guelpen; Alicia K. Heath; Keren Papier; Tammy Y.N. Tong; Scott A. Summers; Mary Playdon; Amanda J. Cross; Pekka Keski-Rahkonen; Véronique Chajès; Neil Murphy; Marc J. Gunter
Source
EBioMedicine, Vol 101, Iss , Pp 105024- (2024)
Subject
Language
English
ISSN
2352-3964
75776340
75776340
Abstract
Summary: Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods: In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk. Findings: Of the 97 assayed lipids, 24 were inversely associated (nominally p