학술논문
Improved gut microbiota features after the resolution of SARS‑CoV‑2 infection
Document Type
article
Author
Flavio De Maio; Gianluca Ianiro; Gaetano Coppola; Francesco Santopaolo; Valeria Abbate; Delia Mercedes Bianco; Fabio Del Zompo; Giuseppe De Matteis; Massimo Leo; Antonio Nesci; Alberto Nicoletti; Maurizio Pompili; Giovanni Cammarota; Brunella Posteraro; Maurizio Sanguinetti; Antonio Gasbarrini; Francesca Romana Ponziani
Source
Gut Pathogens, Vol 13, Iss 1, Pp 1-4 (2021)
Subject
Language
English
ISSN
1757-4749
Abstract
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking. Methods We enrolled 30 patients hospitalized for SARS‑CoV‑2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization. Results Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (≈ 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p = 0.004). Conversely, Firmicutes were prevalent (≈ 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p = 0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition. Conclusion SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period.