학술논문
Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project)
Document Type
article
Author
Costanza Maria Donati; Gabriella Macchia; Giambattista Siepe; Alice Zamagni; Anna Benini; Francesco Cellini; Milly Buwenge; Savino Cilla; Silvia Cammelli; Stefania Rizzo; Luciana Caravatta; Tigeneh Wondemagegnhu; A. F. M. Kamal Uddin; Biniyam Tefera Deressa; Mostafa A. Sumon; Elisa Lodi Rizzini; Alberto Bazzocchi; Alessio G. Morganti; Francesco Deodato; Eleonora Farina
Source
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Previous trials showed the tolerability and efficacy of a palliative radiotherapy (RT) regimen (SHARON) based on the 4 fractions delivered in 2 days in different oncological settings. In order to identify possible predictors of symptomatic response, the purpose of this study is to perform a pooled analysis of previous trials. We analyzed the impact on symptomatic response of the following parameters: tumor site, histological type, performance status (ECOG), dominant symptom, and RT dose using the Chi-square test and Fisher’s exact test. One-hundred-eighty patients were analyzed. Median RT dose was 20 Gy (range: 14–20 Gy). The overall response rate was 88.8% (95% CI 83.3–92.7%) while pre- and post-treatment mean VAS was 5.3 (± 7.7) and 2.2 (± 2.2), respectively (p 7) pain (36.0% vs 14.3%; p = 0.028). This pooled analysis showed high efficacy of the SHARON regimen in the relief of several cancer-related symptoms. The markedly and significantly higher complete pain response rate, in patients with mild-moderate pain, suggests early referral to palliative RT for patients with cancer-related pain.