학술논문
Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation
Document Type
article
Author
Elena Tassi; Maddalena Noviello; Pantaleo De Simone; Maria T. Lupo-Stanghellini; Matteo Doglio; Francesca Serio; Danilo Abbati; Valeria Beretta; Veronica Valtolina; Giacomo Oliveira; Sara Racca; Edoardo Campodonico; Eliana Ruggiero; Daniela Clerici; Fabio Giglio; Francesca Lorentino; Roee Dvir; Elisabetta Xue; Francesca Farina; Chiara Oltolini; Francesco Manfredi; Luca Vago; Consuelo Corti; Massimo Bernardi; Massimo Clementi; Liselotte Brix; Fabio Ciceri; Jacopo Peccatori; Raffaella Greco; Chiara Bonini
Source
Haematologica, Vol 108, Iss 6 (2022)
Subject
Language
English
ISSN
0390-6078
1592-8721
1592-8721
Abstract
After allogeneic hematopoietic stem cell transplantation (HSCT), the emergence of circulating cytomegalovirus (CMV)- specific T cells correlates with protection from CMV reactivation, an important risk factor for non-relapse mortality. However, functional assays measuring CMV-specific cells are time-consuming and often inaccurate at early time-points. We report the results of a prospective single-center, non-interventional study that identified the enumeration of Dextramerpositive CMV-specific lymphocytes as a reliable and early predictor of viral reactivation. We longitudinally monitored 75 consecutive patients for 1 year after allogeneic HSCT (n=630 samples). The presence of ≥0.5 CMV-specific CD8+ cells/mL at day +45 was an independent protective factor from subsequent clinically relevant reactivation in univariate (P