학술논문
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
Document Type
article
Author
Linda Kachuri; Mattias Johansson; Sara R. Rashkin; Rebecca E. Graff; Yohan Bossé; Venkata Manem; Neil E. Caporaso; Maria Teresa Landi; David C. Christiani; Paolo Vineis; Geoffrey Liu; Ghislaine Scelo; David Zaridze; Sanjay S. Shete; Demetrius Albanes; Melinda C. Aldrich; Adonina Tardón; Gad Rennert; Chu Chen; Gary E. Goodman; Jennifer A. Doherty; Heike Bickeböller; John K. Field; Michael P. Davies; M. Dawn Teare; Lambertus A. Kiemeney; Stig E. Bojesen; Aage Haugen; Shanbeh Zienolddiny; Stephen Lam; Loïc Le Marchand; Iona Cheng; Matthew B. Schabath; Eric J. Duell; Angeline S. Andrew; Jonas Manjer; Philip Lazarus; Susanne Arnold; James D. McKay; Nima C. Emami; Matthew T. Warkentin; Yonathan Brhane; Ma’en Obeidat; Richard M. Martin; Caroline Relton; George Davey Smith; Philip C. Haycock; Christopher I. Amos; Paul Brennan; John S. Witte; Rayjean J. Hung
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune-related pathways