학술논문
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
Document Type
article
Author
Yan Dora Zhang; Amber N. Hurson; Haoyu Zhang; Parichoy Pal Choudhury; Douglas F. Easton; Roger L. Milne; Jacques Simard; Per Hall; Kyriaki Michailidou; Joe Dennis; Marjanka K. Schmidt; Jenny Chang-Claude; Puya Gharahkhani; David Whiteman; Peter T. Campbell; Michael Hoffmeister; Mark Jenkins; Ulrike Peters; Li Hsu; Stephen B. Gruber; Graham Casey; Stephanie L. Schmit; Tracy A. O’Mara; Amanda B. Spurdle; Deborah J. Thompson; Ian Tomlinson; Immaculata De Vivo; Maria Teresa Landi; Matthew H. Law; Mark M. Iles; Florence Demenais; Rajiv Kumar; Stuart MacGregor; D. Timothy Bishop; Sarah V. Ward; Melissa L. Bondy; Richard Houlston; John K. Wiencke; Beatrice Melin; Jill Barnholtz-Sloan; Ben Kinnersley; Margaret R. Wrensch; Christopher I. Amos; Rayjean J. Hung; Paul Brennan; James McKay; Neil E. Caporaso; Sonja I. Berndt; Brenda M. Birmann; Nicola J. Camp; Peter Kraft; Nathaniel Rothman; Susan L. Slager; Andrew Berchuck; Paul D. P. Pharoah; Thomas A. Sellers; Simon A. Gayther; Celeste L. Pearce; Ellen L. Goode; Joellen M. Schildkraut; Kirsten B. Moysich; Laufey T. Amundadottir; Eric J. Jacobs; Alison P. Klein; Gloria M. Petersen; Harvey A. Risch; Rachel Z. Stolzenberg-Solomon; Brian M. Wolpin; Donghui Li; Rosalind A. Eeles; Christopher A. Haiman; Zsofia Kote-Jarai; Fredrick R. Schumacher; Ali Amin Al Olama; Mark P. Purdue; Ghislaine Scelo; Marlene D. Dalgaard; Mark H. Greene; Tom Grotmol; Peter A. Kanetsky; Katherine A. McGlynn; Katherine L. Nathanson; Clare Turnbull; Fredrik Wiklund; Breast Cancer Association Consortium (BCAC); Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON); Colon Cancer Family Registry (CCFR); Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT); Endometrial Cancer Association Consortium (ECAC); Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO); Melanoma Genetics Consortium (GenoMEL); Glioma International Case-Control Study (GICC); International Lung Cancer Consortium (ILCCO); Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium; International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph); Ovarian Cancer Association Consortium (OCAC); Oral Cancer GWAS; Pancreatic Cancer Case-Control Consortium (PanC4); Pancreatic Cancer Cohort Consortium (PanScan); Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL); Renal Cancer GWAS; Testicular Cancer Consortium (TECAC); Stephen J. Chanock; Nilanjan Chatterjee; Montserrat Garcia-Closas
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and show the utility of polygenic risk scores may vary depending on cancer type.