학술논문
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
Document Type
article
Author
Monika Graf; Marta Interlandi; Natalia Moreno; Dörthe Holdhof; Carolin Göbel; Viktoria Melcher; Julius Mertins; Thomas K. Albert; Dennis Kastrati; Amelie Alfert; Till Holsten; Flavia de Faria; Michael Meisterernst; Claudia Rossig; Monika Warmuth-Metz; Johannes Nowak; Gerd Meyer zu Hörste; Chloe Mayère; Serge Nef; Pascal Johann; Michael C. Frühwald; Martin Dugas; Ulrich Schüller; Kornelius Kerl
Source
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Rhabdoid tumors (RT) are aggressive paediatric cancers with yet unknown cells of origin. Here, the authors establish genetically engineered mouse models of RT and, using single-cell RNA-seq and epigenomics, identify potential cells of origin for the SHH and MYC subtypes.