학술논문
The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life
Document Type
article
Author
Miriam A. Lynn; Georgina Eden; Feargal J. Ryan; Julien Bensalem; Xuemin Wang; Stephen J. Blake; Jocelyn M. Choo; Yee Tee Chern; Anastasia Sribnaia; Jane James; Saoirse C. Benson; Lauren Sandeman; Jianling Xie; Sofia Hassiotis; Emily W. Sun; Alyce M. Martin; Marianne D. Keller; Damien J. Keating; Timothy J. Sargeant; Christopher G. Proud; Steve L. Wesselingh; Geraint B. Rogers; David J. Lynn
Source
Cell Reports, Vol 36, Iss 8, Pp 109564- (2021)
Subject
Language
English
ISSN
2211-1247
Abstract
Summary: Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice. We demonstrate the emergence of two different low-diversity community types, post-antibiotic microbiota (PAM) I and PAM II, following antibiotic exposure. PAM II but not PAM I mice have impaired immunity, increased insulin resistance, and evidence of increased inflammaging in later life as well as a reduced lifespan. Our data suggest that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.