학술논문
Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study
Document Type
article
Author
Fanny Senner; Lena Hiendl; Susanne Bengesser; Kristina Adorjan; Ion-George Anghelescu; Bernhardt T. Baune; Monika Budde; Udo Dannlowski; Detlef E. Dietrich; Peter Falkai; Andreas J. Fallgatter; Alkomiet Hasan; Maria Heilbronner; Markus Jäger; Georg Juckel; Janos L. Kalman; Carsten Konrad; Mojtaba Oraki Kohshour; Sergi Papiol; Daniela Reich-Erkelenz; Jens Reimer; Sabrina K. Schaupp; Max Schmauß; Simon Senner; Carsten Spitzer; Thomas Vogl; Jörg Zimmermann; Urs Heilbronner; Eva C. Schulte; Thomas G. Schulze; Eva Z. Reininghaus; Sophie-Kathrin Kirchner; Nina Dalkner
Source
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Subject
Language
English
ISSN
2158-3188
Abstract
Abstract Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatment adherence can prevent exacerbations and re-hospitalizations. To date, the relationship between medication adherence and cognitive performance is understudied. Therefore, this study investigated the relationship between medication adherence and cognitive performance by analyzing the data of 862 participants with schizophrenia-spectrum and bipolar disorders (mean [SD] age, 41.9 [12.48] years; 44.8% female) from a multicenter study (PsyCourse Study). Z-scores for three cognitive domains were calculated, global functioning was measured with the Global Assessment of Functioning Scale, and adherence was assessed by a self-rating questionnaire. We evaluated four multiple linear regression models and built three clusters with hierarchical cluster analyses. Higher adherence behavior (p