학술논문
Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
Document Type
article
Author
Belén Peñalver-Argüeso; Esther García-Esquinas; Adela Castelló; Nerea Fernández de Larrea-Baz; Gemma Castaño-Vinyals; Pilar Amiano; Tania Fernández-Villa; Marcela Guevara; Guillermo Fernández-Tardón; Juan Alguacil; Mireia Obón-Santacana; Inés Gómez-Acebo; Marina Pinto-Carbó; Rafael Marcos-Gragera; Nuria Aragonés; Amaia Aizpurua; Vicente Martín-Sánchez; Eva Ardanaz; Trinidad Dierssen-Sotos; Jose Juan Jiménez-Moleón; Manolis Kogevinas; Marina Pollán; Beatriz Pérez-Gómez
Source
Tobacco Induced Diseases, Vol 21, Iss November, Pp 1-16 (2023)
Subject
Language
English
ISSN
1617-9625
Abstract
Introduction The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models. Results Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04–2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ≥10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11–0.68); p for heterogeneity = 0.040). Also, those who had smoked