학술논문
Short‐Term Changes in Left and Right Ventricular Cardiac Magnetic Resonance Feature Tracking Strain Following Ferric Carboxymaltose in Patients With Heart Failure: A Substudy of the Myocardial‐IRON Trial
Document Type
article
Author
Irene del Canto; Enrique Santas; Ingrid Cardells; Gema Miñana; Patricia Palau; Pau Llàcer; Lorenzo Fácila; Raquel López‐Vilella; Luis Almenar; Vicent Bodí; Maria P. López‐Lereu; Jose V. Monmeneu; Juan Sanchis; David Moratal; Alicia M. Maceira; Rafael de la Espriella; Francisco J. Chorro; Antoni Bayés‐Genís; Julio Núñez
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Subject
Language
English
ISSN
2047-9980
Abstract
Background The mechanisms explaining the clinical benefits of ferric carboximaltose (FCM) in patients with heart failure, reduced or intermediate left ventricular ejection fraction, and iron deficiency remain not fully clarified. The Myocardial‐IRON trial showed short‐term cardiac magnetic resonance (CMR) changes suggesting myocardial iron repletion following administration of FCM but failed to find a significant increase in left ventricular ejection fraction in the whole sample. Conversely, the strain assessment could evaluate more specifically subtle changes in contractility. In this subanalysis, we aimed to evaluate the effect of FCM on the short‐term left and right ventricular CMR feature tracking derived strain. Methods and Results This is a post hoc subanalysis of the double‐blind, placebo‐controlled, randomized clinical trial that enrolled 53 ambulatory patients with heart failure and left ventricular ejection fraction