학술논문
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
Document Type
article
Author
Kevin Huynh; Wei Ling Florence Lim; Corey Giles; Kaushala S. Jayawardana; Agus Salim; Natalie A. Mellett; Adam Alexander T. Smith; Gavriel Olshansky; Brian G. Drew; Pratishtha Chatterjee; Ian Martins; Simon M. Laws; Ashley I. Bush; Christopher C. Rowe; Victor L. Villemagne; David Ames; Colin L. Masters; Matthias Arnold; Kwangsik Nho; Andrew J. Saykin; Rebecca Baillie; Xianlin Han; Rima Kaddurah-Daouk; Ralph N. Martins; Peter J. Meikle
Source
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.