학술논문
Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes
Document Type
article
Author
Jian L. Yeo; Gaurav S. Gulsin; Emer M. Brady; Abhishek Dattani; Joanna M. Bilak; Anna-Marie Marsh; Manjit Sian; Lavanya Athithan; Kelly S. Parke; Joanne Wormleighton; Matthew P. M. Graham-Brown; Anvesha Singh; J. Ranjit Arnold; Claire Lawson; Melanie J. Davies; Hui Xue; Peter Kellman; Gerry P. McCann
Source
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
1475-2840
Abstract
Abstract Background Type 2 diabetes (T2D) and hypertension commonly coexist and are associated with subclinical myocardial structural and functional changes. We sought to determine the association between blood pressure (BP) and left ventricular (LV) remodeling, systolic/diastolic function, and coronary microvascular function, among individuals with T2D without prevalent cardiovascular disease. Methods Participants with T2D and age-, sex-, and ethnicity-matched controls underwent comprehensive cardiovascular phenotyping including fasting bloods, transthoracic echocardiography, cardiovascular magnetic resonance imaging with quantitative adenosine stress/rest perfusion, and office and 24-h ambulatory BP monitoring. Multivariable linear regression was performed to determine independent associations between BP and imaging markers of remodeling and function in T2D. Results Individuals with T2D (n = 205, mean age 63 ± 7 years) and controls (n = 40, mean age 61 ± 8 years) were recruited. Mean 24-h systolic BP, but not office BP, was significantly greater among those with T2D compared to controls (128.8 ± 11.7 vs 123.0 ± 13.1 mmHg, p = 0.006). Those with T2D had concentric LV remodeling (mass/volume 0.91 ± 0.15 vs 0.82 ± 0.11 g/mL, p