학술논문
Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
Document Type
article
Author
Source
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Abstract Many chronic disease symptomatologies involve desynchronized sleep-wake cycles, indicative of disrupted biorhythms. This can be interrogated using body temperature rhythms, which have circadian as well as sleep-wake behavior/environmental evoked components. Here, we investigated the association of wrist temperature amplitudes with a future onset of disease in the UK Biobank one year after actigraphy. Among 425 disease conditions (range n = 200-6728) compared to controls (range n = 62,107-91,134), a total of 73 (17%) disease phenotypes were significantly associated with decreased amplitudes of wrist temperature (Benjamini-Hochberg FDR q