학술논문
A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre
Document Type
article
Author
Source
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-9 (2018)
Subject
Language
English
ISSN
1471-2334
Abstract
Abstract Background Tuberculosis (TB) recurrence represents a challenge to control programs. In low incidence countries, the prevailing risk factors leading to recurrence are poorly characterised. Methods We conducted a nested case–control study using the Leicester TB service TBIT database. Cases were identified from database notifications between 1994 and 2014. Controls had one episode and were matched to cases on a ratio of two to one by the date of notification. Multiple imputation was used to account for missing data. Multivariate conditional logistic regression analysis was employed to identify clinical, sociodemographic and TB specific risk factors for recurrence. Results From a cohort of 4628 patients, 82 TB recurrences occurred (1.8%). Nineteen of 82 patients had paired isolates with MIRU-VNTR strain type profiles available, of which 84% were relapses and 16% reinfections. On multivariate analysis, smoking (OR 3.8; p = 0.04), grade 3/4 adverse drug reactions (OR 5.6; p = 0.02), ethnicity ‘Indian subcontinent’ (OR 8.5; p =