학술논문
Untangling the relationship between smoking and systemic sclerosis: an analysis of the EUSTAR cohort
Document Type
article
Author
Marco Matucci-Cerinic; Tom W J Huizinga; Paolo Airo; Jeska De Vries-Bouwstra; Elisabetta Zanatta; László Czirják; Piotr Wiland; Tatsuya Atsumi; Suzanne Cannegieter; Saad Ahmed; Gabriella Szücs; Francesco Ursini; Ina Koetter; Alexandra Balbir Gurman; Joerg C Henes; Jacopo Ciaffi; Sophie I E Liem; Eva M Hoekstra; EUSTAR Collaborators
Source
RMD Open, Vol 10, Iss 2 (2024)
Subject
Language
English
ISSN
2056-5933
Abstract
Objectives To untangle the association between smoking and systemic sclerosis (SSc).Methods In the European Scleroderma Trials and Research cohort, the autoantibody status was compared between ever-smokers and never-smokers. Time until disease progression was assessed using Kaplan-Meier curves. Cox models were built to investigate the influence of smoking over 15 years of follow-up. All analyses were performed for the total cohort and stratified for sex and for positivity of anti-centromere (ACA) and anti-topoisomerase antibodies (ATA).Results Overall, 12 314 patients were included in the study. Of these, 10 393 were women (84%), 4637 were ACA-positive (38%), 3919 were ATA-positive (32%) and 4271 (35%) were ever-smokers. In men, but not in women, smoking was associated with mortality (HR 1.63, 95% CI 1.23 to 2.16, p=0.001). Ever-smoking women were at higher risk for skin progression (HR 1.10, 95% CI 1.00 to 1.22, p=0.046) and for ‘any organ progression’ (HR 1.07, 95% CI 1.00 to 1.13, p=0.036). In women, 34% of never-smokers were ATA-positive compared with 21% of ever-smokers (p