학술논문
Peripheral quantitative computed tomography in the assessment of bone mineral density in anti-TNF-treated rheumatoid arthritis and ankylosing spondylitis patients
Document Type
article
Author
Balázs Juhász; Katalin Gulyás; Ágnes Horváth; Edit Végh; Anita Pusztai; Ágnes Szentpétery; Zsófia Pethő; Nóra Bodnár; Attila Hamar; Levente Bodoki; Harjit Pal Bhattoa; Éva Szekanecz; Katalin Hodosi; Andrea Domján; Szilvia Szamosi; Csaba Horváth; Sándor Szántó; Gabriella Szűcs; Hennie G. Raterman; Willem F. Lems; Oliver FitzGerald; Zoltán Szekanecz
Source
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-9 (2021)
Subject
Language
English
ISSN
1471-2474
Abstract
Abstract Introduction Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are associated with osteoporosis. There have not been many peripheral quantitative computed tomography (QCT) studies in patients receiving biologics. We assessed volumetric and areal bone mineral density (BMD) by forearm QCT and dual-energy X-ray absorptiometry (DXA), respectively in addition to laboratory biomarkers in these arthritides. Methods Forty RA and AS patients treated with either etanercept (ETN) or certolizumab pegol (CZP) were undergoing follow-ups for one year. Volumetric and areal BMD, as well as parathyroid hormone (PTH), osteocalcin, RANKL, 25-hydroxyvitamin D (VITD), P1NP, CTX, sclerostin (SOST), Dickkopf 1 (DKK-1) and cathepsin K (CATHK) were determined. Results We did not observe any further bone loss during the 12-month treatment period. Volumetric and areal BMD showed significant correlations with each other (p