학술논문
Associations of vascular and bone status in arthritis patients
Document Type
article
Author
Anita Pusztai; Attila Hamar; Monika Czókolyová; Katalin Gulyás; Ágnes Horváth; Edit Végh; Zsófia Pethő; Szilvia Szamosi; Emese Balogh; Nóra Bodnár; Levente Bodoki; Ágnes Szentpétery; Harjit Pal Bhattoa; György Kerekes; Balázs Juhász; Éva Szekanecz; Katalin Hodosi; Andrea Domján; Sándor Szántó; Hennie G. Raterman; Willem F. Lems; Zoltán Szekanecz; Gabriella Szűcs
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Cardiovascular (CV) disease and osteoporosis (OP) have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Bone and vascular biomarkers and parameters along with the effect of 1-year anti-TNF therapy on these markers were assessed in order to determine correlations between vascular pathophysiology and bone metabolism in RA and AS. Thirty-six patients treated with etanercept or certolizumab pegol and 17 AS patients treated with ETN were included in a 12-month follow-up study. Bone and vascular markers were previously assessed by ELISA. Bone density was measured by DXA and quantitative CT (QCT). Flow-mediated vasodilation (FMD), common carotid intima-media thickness (IMT) and pulse-wave velocity (PWV) were assessed by ultrasound. Multiple correlation analyses indicated associations between bone and vascular markers. Osteoprotegerin, sclerostin and cathepsin K were significantly associated with FMD, IMT and PWV, respectively (p