부산대학교 도서관

OBJECTIVES:Try to find out the frequency of isolated fetal pyelectasis and its association with abnormal fetal karyotypes in a high risk pregnant population STUDY DESING :759 pregnants with advanced maternal age or with increased risk for trisomy 21 in triple tests were enrolled into the study.Ultrasonographic examinations and amniocentesis were performed for all pregnants at 15-21 weeks of their gestations RESULTS:649 pregnants completed the study protocol.424 cases had advanced maternal age and 225 cases had increased risk for trisomy 21. There were 15 cases (2.31%) with isolated pyelectasis and these cases had normal karyotypes except a normal variance(46 XX inv9p11q13).There were 14 (3.30%) chromosomal abnormalities in advanced maternal age group and 7 (3.11%) in pregnants with increased risk in triple tests. CONCLUSION:Although inreased risk of Down’s Syndrome is not high in pregnants with isolated fetal pyelectasis, they should be followed and searched for other findings of aneuploidy.