학술논문
Antiaging effect of a Jianpi-yangwei formula in Caenorhabditis elegans
Document Type
article
Author
Source
BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
Subject
Language
English
ISSN
1472-6882
Abstract
Abstract Background Jianpi-yangwei (JPYW), a traditional Chinese medicine (TCM), helps to nourish the stomach and spleen and is primarily used to treat functional declines related to aging. This study aimed to explore the antiaging effects and mechanism of JPYW by employing a Caenorhabditis elegans model. Methods Wild-type C. elegans N2 worms were cultured in growth medium with or without JPYW, and lifespan analysis, oxidative and heat stress resistance assays, and other aging-related assays were performed. The effects of JPYW on the levels of superoxide dismutase (SOD) and the expression of specific genes were examined to explore the underlying mechanism of JPYW. Results Compared to control worms, JPYW-treated wild-type worms showed increased survival times under both normal and stress conditions (P