학술논문
Cross-sectional surveys of measles antibodies in the Jiangsu Province of China from 2008 to 2010: the effect of high coverage with two doses of measles vaccine among children.
Document Type
article
Author
Source
PLoS ONE, Vol 8, Iss 6, p e66771 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
BACKGROUND: Changes in the epidemiological characteristics of measles since 2007 appeared in the Jiangsu province. Although the reported coverage with two doses of measles vaccine was greater than 95% in most regions of the province, measles incidence remained high across the whole province. Cross-sectional serological surveys of measles antibodies in the Jiangsu province of China were conducted from 2008 to 2010 to assess and track population immunity. METHODS: Measles-specific IgG levels were measured in serum samples using ELISA. GMTs and seroprevalence with 95% CIs were calculated by region, gender, and age. ANOVA and χ(2) tests were used to test for statistically significant differences between groups for GMT levels and seroprevalence, respectively. RESULTS: Seroprevalence showed a significantly increasing trend annually (CMH χ(2) = 40.32, p