학술논문
XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
Document Type
article
Author
Li‐Xiang Yu; Li‐Yuan Liu; Yu‐Juan Xiang; Fei Wang; Fei Zhou; Shu‐Ya Huang; Chao Zheng; Chun‐Miao Ye; Wen‐Zhong Zhou; Geng‐Shen Yin; Jia‐Lin Zhang; Shu‐De Cui; Fu‐Guo Tian; Zhi‐Min Fan; Cui‐Zhi Geng; Xu‐Chen Cao; Zhen‐Lin Yang; Xiang Wang; Hong Liang; Shu Wang; Hong‐Chuan Jiang; Xue‐Ning Duan; Hai‐Bo Wang; Guo‐Lou Li; Qi‐Tang Wang; Jian‐Guo Zhang; Feng Jin; Jin‐Hai Tang; Liang Li; Shi‐Guang Zhu; Wen‐Shu Zuo; Zhong‐Bing Ma; Zhi‐Gang Yu
Source
Cancer Medicine, Vol 10, Iss 8, Pp 2752-2762 (2021)
Subject
Language
English
ISSN
2045-7634
Abstract
Abstract Background X‐ray repair cross‐complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. Methods The study included 1039 patients with breast cancer and 1040 controls. Four single‐nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene‐environment interactions were analyzed using logistic regression with multiplicative interaction models. Results XRCC5 rs16855458 was associated with increased breast cancer risk in the co‐dominant (ptrend = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07–1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor‐negative/progesterone receptor‐negative (ER−/PR−) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12–2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (pinteraction = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (pinteraction = 0.0497). However, these interactions became insignificant after Bonferroni correction. Conclusion XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER−/PR− breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation.