학술논문
The classical pathway triggers pathogenic complement activation in membranous nephropathy
Document Type
article
Author
Larissa Seifert; Gunther Zahner; Catherine Meyer-Schwesinger; Naemi Hickstein; Silke Dehde; Sonia Wulf; Sarah M. S. Köllner; Renke Lucas; Dominik Kylies; Sarah Froembling; Stephanie Zielinski; Oliver Kretz; Anna Borodovsky; Sergey Biniaminov; Yanyan Wang; Hong Cheng; Friedrich Koch-Nolte; Peter F. Zipfel; Helmut Hopfer; Victor G. Puelles; Ulf Panzer; Tobias B. Huber; Thorsten Wiech; Nicola M. Tomas
Source
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and a pathogenic driver of the disease.