학술논문
Links between gut microbiome composition and fatty liver disease in a large population sample
Document Type
article
Author
Source
Gut Microbes, Vol 13, Iss 1 (2021)
Subject
Language
English
ISSN
1949-0976
1949-0984
19490976
1949-0984
19490976
Abstract
Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we studied the link between the Fatty Liver Index (FLI), a well-established proxy for fatty liver disease, and gut microbiome composition in a representative, ethnically homogeneous population sample of 6,269 Finnish participants. We based our models on biometric covariates and gut microbiome compositions from shallow metagenome sequencing. Our classification models could discriminate between individuals with a high FLI (≥60, indicates likely liver steatosis) and low FLI (