학술논문
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
Document Type
article
Author
Mitchell J. Machiela; Weiyin Zhou; Eric Karlins; Joshua N. Sampson; Neal D. Freedman; Qi Yang; Belynda Hicks; Casey Dagnall; Christopher Hautman; Kevin B. Jacobs; Christian C. Abnet; Melinda C. Aldrich; Christopher Amos; Laufey T. Amundadottir; Alan A. Arslan; Laura E. Beane-Freeman; Sonja I. Berndt; Amanda Black; William J. Blot; Cathryn H. Bock; Paige M. Bracci; Louise A. Brinton; H Bas Bueno-de-Mesquita; Laurie Burdett; Julie E. Buring; Mary A. Butler; Federico Canzian; Tania Carreón; Kari G. Chaffee; I-Shou Chang; Nilanjan Chatterjee; Chu Chen; Constance Chen; Kexin Chen; Charles C. Chung; Linda S. Cook; Marta Crous Bou; Michael Cullen; Faith G. Davis; Immaculata De Vivo; Ti Ding; Jennifer Doherty; Eric J. Duell; Caroline G. Epstein; Jin-Hu Fan; Jonine D. Figueroa; Joseph F. Fraumeni; Christine M. Friedenreich; Charles S. Fuchs; Steven Gallinger; Yu-Tang Gao; Susan M. Gapstur; Montserrat Garcia-Closas; Mia M. Gaudet; J. Michael Gaziano; Graham G. Giles; Elizabeth M. Gillanders; Edward L. Giovannucci; Lynn Goldin; Alisa M. Goldstein; Christopher A. Haiman; Goran Hallmans; Susan E. Hankinson; Curtis C. Harris; Roger Henriksson; Elizabeth A. Holly; Yun-Chul Hong; Robert N. Hoover; Chao A. Hsiung; Nan Hu; Wei Hu; David J. Hunter; Amy Hutchinson; Mazda Jenab; Christoffer Johansen; Kay-Tee Khaw; Hee Nam Kim; Yeul Hong Kim; Young Tae Kim; Alison P. Klein; Robert Klein; Woon-Puay Koh; Laurence N. Kolonel; Charles Kooperberg; Peter Kraft; Vittorio Krogh; Robert C. Kurtz; Andrea LaCroix; Qing Lan; Maria Teresa Landi; Loic Le Marchand; Donghui Li; Xiaolin Liang; Linda M. Liao; Dongxin Lin; Jianjun Liu; Jolanta Lissowska; Lingeng Lu; Anthony M. Magliocco; Nuria Malats; Keitaro Matsuo; Lorna H. McNeill; Robert R. McWilliams; Beatrice S. Melin; Lisa Mirabello; Lee Moore; Sara H. Olson; Irene Orlow; Jae Yong Park; Ana Patiño-Garcia; Beata Peplonska; Ulrike Peters; Gloria M. Petersen; Loreall Pooler; Jennifer Prescott; Ludmila Prokunina-Olsson; Mark P. Purdue; You-Lin Qiao; Preetha Rajaraman; Francisco X. Real; Elio Riboli; Harvey A. Risch; Benjamin Rodriguez-Santiago; Avima M. Ruder; Sharon A. Savage; Fredrick Schumacher; Ann G. Schwartz; Kendra L. Schwartz; Adeline Seow; Veronica Wendy Setiawan; Gianluca Severi; Hongbing Shen; Xin Sheng; Min-Ho Shin; Xiao-Ou Shu; Debra T. Silverman; Margaret R. Spitz; Victoria L. Stevens; Rachael Stolzenberg-Solomon; Daniel Stram; Ze-Zhong Tang; Philip R. Taylor; Lauren R. Teras; Geoffrey S. Tobias; David Van Den Berg; Kala Visvanathan; Sholom Wacholder; Jiu-Cun Wang; Zhaoming Wang; Nicolas Wentzensen; William Wheeler; Emily White; John K. Wiencke; Brian M. Wolpin; Maria Pik Wong; Chen Wu; Tangchun Wu; Xifeng Wu; Yi-Long Wu; Jay S. Wunder; Lucy Xia; Hannah P. Yang; Pan-Chyr Yang; Kai Yu; Krista A. Zanetti; Anne Zeleniuch-Jacquotte; Wei Zheng; Baosen Zhou; Regina G. Ziegler; Luis A. Perez-Jurado; Neil E. Caporaso; Nathaniel Rothman; Margaret Tucker; Michael C. Dean; Meredith Yeager; Stephen J. Chanock
Source
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk