학술논문
Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly
Document Type
article
Author
Peggy Riese; Stephanie Trittel; Manas K. Akmatov; Marcus May; Jana Prokein; Thomas Illig; Christoph Schindler; Birgit Sawitzki; Yassin Elfaki; Stefan Floess; Jochen Huehn; Adrian J. Błażejewski; Till Strowig; Esteban A. Hernandez-Vargas; Robert Geffers; Bowen Zhang; Yang Li; Frank Pessler; Carlos A. Guzmán
Source
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary. Here authors establish, with an array of state-of-the art methods, the major immunological parameters that distinguish vaccine recipients developing robust antibody response and non-responders