학술논문
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Document Type
article
Author
Heming Wang; Jacqueline M. Lane; Samuel E. Jones; Hassan S. Dashti; Hanna M. Ollila; Andrew R. Wood; Vincent T. van Hees; Ben Brumpton; Bendik S. Winsvold; Katri Kantojärvi; Teemu Palviainen; Brian E. Cade; Tamar Sofer; Yanwei Song; Krunal Patel; Simon G. Anderson; David A. Bechtold; Jack Bowden; Richard Emsley; Simon D. Kyle; Max A. Little; Andrew S. Loudon; Frank A. J. L. Scheer; Shaun M. Purcell; Rebecca C. Richmond; Kai Spiegelhalder; Jessica Tyrrell; Xiaofeng Zhu; Christer Hublin; Jaakko A. Kaprio; Kati Kristiansson; Sonja Sulkava; Tiina Paunio; Kristian Hveem; Jonas B. Nielsen; Cristen J. Willer; John-Anker Zwart; Linn B. Strand; Timothy M. Frayling; David Ray; Deborah A. Lawlor; Martin K. Rutter; Michael N. Weedon; Susan Redline; Richa Saxena
Source
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
A main symptom of chronic insufficient sleep is excessive daytime sleepiness. Here, Wang et al. report 42 genome-wide significant loci for self-reported daytime sleepiness in 452,071 individuals from the UK Biobank that cluster into two biological subtypes of either sleep propensity or sleep fragmentation.