학술논문
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells
Document Type
article
Author
Clément Larrue; Nathan Guiraud; Pierre-Luc Mouchel; Marine Dubois; Thomas Farge; Mathilde Gotanègre; Claudie Bosc; Estelle Saland; Marie-Laure Nicolau-Travers; Marie Sabatier; Nizar Serhan; Ambrine Sahal; Emeline Boet; Sarah Mouche; Quentin Heydt; Nesrine Aroua; Lucille Stuani; Tony Kaoma; Linus Angenendt; Jan-Henrik Mikesch; Christoph Schliemann; François Vergez; Jérôme Tamburini; Christian Récher; Jean-Emmanuel Sarry
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Leukemic stem cells which are resistant to chemotherapy are proposed as relapse-initiating cells (RICs). Here, the authors show that targeting the adrenomedullin-calcitonin receptor-like receptor decreases RICs frequency improving chemotherapy response in AML preclinical models.