학술논문
Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside
Document Type
article
Author
Guillaume Carteaux; Manuella Pons; François Morin; Samuel Tuffet; Arnaud Lesimple; Bilal Badat; Anne-Fleur Haudebourg; François Perier; Yvon Deplante; Constance Guillaud; Frédéric Schlemmer; Elena Fois; Nicolas Mongardon; Mehdi Khellaf; Karim Jaffal; Camille Deguillard; Philippe Grimbert; Raphaëlle Huguet; Keyvan Razazi; Nicolas de Prost; François Templier; François Beloncle; Alain Mercat; Laurent Brochard; Vincent Audard; Pascal Lim; Jean-Christophe Richard; Dominique Savary; Armand Mekontso Dessap
Source
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2110-5820
Abstract
Abstract Background We describe a frugal approach (focusing on needs, performance, and costs) to manage a massive influx of COVID-19 patients with acute hypoxemic respiratory failure (AHRF) using the Boussignac valve protected by a filter (“Filter Frugal CPAP”, FF-CPAP) in and out the ICU. Methods (1) A bench study measured the impact of two filters with different mechanical properties on CPAP performances, and pressures were also measured in patients. (2) Non-ICU healthcare staff working in COVID-19 intermediate care units were trained with a video tutorial posted on a massive open online course. (3) A clinical study assessed the feasibility and safety of using FF-CPAP to maintain oxygenation and manage patients out of the ICU during a massive outbreak. Results Bench assessments showed that adding a filter did not affect the effective pressure delivered to the patient. The resistive load induced by the filter variably increased the simulated patient’s work of breathing (6–34%) needed to sustain the tidal volume, depending on the filter’s resistance, respiratory mechanics and basal inspiratory effort. In patients, FF-CPAP achieved pressures similar to those obtained on the bench. The massive training tool provided precious information on the use of Boussignac FF-CPAP on COVID-19 patients. Then 85 COVID-19 patients with ICU admission criteria over a 1-month period were studied upon FF-CPAP initiation for AHRF. FF-CPAP significantly decreased respiratory rate and increased SpO2. Thirty-six (43%) patients presented with respiratory indications for intubation prior to FF-CPAP initiation, and 13 (36%) of them improved without intubation. Overall, 31 patients (36%) improved with FF-CPAP alone and 17 patients (20%) did not require ICU admission. Patients with a respiratory rate > 32 breaths/min upon FF-CPAP initiation had a higher cumulative probability of intubation (p