학술논문
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
Document Type
article
Author
Benjamin A. Nacev; Francisco Sanchez-Vega; Shaleigh A. Smith; Cristina R. Antonescu; Evan Rosenbaum; Hongyu Shi; Cerise Tang; Nicholas D. Socci; Satshil Rana; Rodrigo Gularte-Mérida; Ahmet Zehir; Mrinal M. Gounder; Timothy G. Bowler; Anisha Luthra; Bhumika Jadeja; Azusa Okada; Jonathan A. Strong; Jake Stoller; Jason E. Chan; Ping Chi; Sandra P. D’Angelo; Mark A. Dickson; Ciara M. Kelly; Mary Louise Keohan; Sujana Movva; Katherine Thornton; Paul A. Meyers; Leonard H. Wexler; Emily K. Slotkin; Julia L. Glade Bender; Neerav N. Shukla; Martee L. Hensley; John H. Healey; Michael P. La Quaglia; Kaled M. Alektiar; Aimee M. Crago; Sam S. Yoon; Brian R. Untch; Sarah Chiang; Narasimhan P. Agaram; Meera R. Hameed; Michael F. Berger; David B. Solit; Nikolaus Schultz; Marc Ladanyi; Samuel Singer; William D. Tap
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencing and find genomic groups that are distinct from histological subgroups.