학술논문
Cortical proteins may provide motor resilience in older adults
Document Type
article
Author
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that provide motor resilience. We studied 1226 older decedents with annual motor testing, postmortem brain pathologies and quantified 226 proteotypic peptides in prefrontal cortex. Twenty peptides remained associated with motor decline in models controlling for ten brain pathologies (FDR