학술논문
Prevalence of familial autoimmune diseases in juvenile idiopathic arthritis: results from the international Pharmachild registry
Document Type
article
Author
Joeri W. van Straalen; Sytze de Roock; Gabriella Giancane; Ekaterina Alexeeva; Elena Koskova; Pablo Mesa-del-Castillo Bermejo; Francesco Zulian; Adele Civino; Davide Montin; Nico M. Wulffraat; Nicolino Ruperto; Joost F. Swart; for the Paediatric Rheumatology International Trials Organisation (PRINTO)
Source
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-10 (2022)
Subject
Language
English
ISSN
1546-0096
Abstract
Abstract Background Little is known about the disposition to autoimmune diseases (ADs) among children diagnosed with JIA. In this study, we provide a comprehensive overview of the prevalence of and factors associated with ADs in parents of children with juvenile idiopathic arthritis (JIA). Methods Prevalence rates of ADs and 95% Poisson confidence intervals were calculated for parents of JIA patients from the international Pharmachild registry and compared with general population prevalence rates as reported in the literature. Demographic, clinical and laboratory features were compared between JIA patients with and without a family history of AD using χ2 and Mann-Whitney U tests. Results Eight thousand six hundred seventy three patients were included and the most common familial ADs were psoriasis, autoimmune thyroid disease, rheumatoid arthritis and ankylosing spondylitis. The prevalence of several ADs was higher in parents of the included JIA patients than in the general population. Clinical Juvenile Arthritis Disease Activity Scores at study entry and last follow-up were not significantly different between patients with (n = 1231) and without a family history of AD (n = 7442). Factors associated with familial AD were older age at JIA onset (P