학술논문
Prevalence of hepatitis D virus infection in Central Italy has remained stable across the last 2 decades with dominance of subgenotypes 1 and characterized by elevated viral replication
Document Type
article
Author
Romina Salpini; Lorenzo Piermatteo; Giulia Torre; Stefano D'Anna; Sohaib Khan; Leonardo Duca; Ada Bertoli; Simone La Frazia; Vincenzo Malagnino; Elisabetta Teti; Marco Iannetta; Pierpaolo Paba; Marco Ciotti; Ilaria Lenci; Simona Francioso; Caterina Paquazzi; Miriam Lichtner; Claudio Mastroianni; Francesco Santopaolo; Giuseppe De Sanctis; Adriano Pellicelli; Giovanni Galati; Alessandra Moretti; Katia Casinelli; Luciano Caterini; Nerio Iapadre; Giustino Parruti; Iacopo Vecchiet; Maurizio Paoloni; Massimo Marignani; Francesca Ceccherini-Silberstein; Leonardo Baiocchi; Sandro Grelli; Loredana Sarmati; Valentina Svicher
Source
International Journal of Infectious Diseases, Vol 138, Iss , Pp 1-9 (2024)
Subject
Language
English
ISSN
1201-9712
Abstract
Objectives: Here we investigate Hepatitis D virus (HDV)-prevalence in Italy and its fluctuations over time and we provide an extensive characterization of HDV-infected patients. Methods: The rate of HDV seroprevalence and HDV chronicity was assessed in 1579 hepatitis B surface antigen (HBsAg)+ patients collected from 2005 to 2022 in Central Italy. Results: In total, 45.3% of HBsAg+ patients received HDV screening with an increasing temporal trend: 15.6% (2005-2010), 45.0% (2011-2014), 49.4% (2015-2018), 71.8% (2019-2022). By multivariable model, factors correlated with the lack of HDV screening were alanine-aminotransferase (ALT) less than two times of upper limit of normality (