학술논문
Clinical behavior and outcomes of breast cancer in young women with germline BRCA pathogenic variants
Document Type
article
Author
Matteo Lambertini; Marcello Ceppi; Anne-Sophie Hamy; Olivier Caron; Philip D. Poorvu; Estela Carrasco; Albert Grinshpun; Kevin Punie; Christine Rousset-Jablonski; Alberta Ferrari; Shani Paluch-Shimon; Angela Toss; Claire Senechal; Fabio Puglisi; Katarzyna Pogoda; Jose Alejandro Pérez-Fidalgo; Laura De Marchis; Riccardo Ponzone; Luca Livraghi; Maria Del Pilar Estevez-Diz; Cynthia Villarreal-Garza; Maria Vittoria Dieci; Florian Clatot; Francois P. Duhoux; Rossella Graffeo; Luis Teixeira; Octavi Córdoba; Amir Sonnenblick; Arlindo R. Ferreira; Ann H. Partridge; Antonio Di Meglio; Claire Saule; Fedro A. Peccatori; Marco Bruzzone; Marie Daphne t’Kint de Roodenbeke; Lieveke Ameye; Judith Balmaña; Lucia Del Mastro; Hatem A. Azim
Source
npj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
Subject
Language
English
ISSN
2374-4677
Abstract
Abstract Young breast cancer (BC) patients carrying a germline BRCA pathogenic variant (mBRCA) have similar outcomes as non-carriers. However, the impact of the type of gene (BRCA1 vs. BRCA2) and hormone receptor status (positive [HR+] vs. negative [HR−]) on clinical behavior and outcomes of mBRCA BC remains largely unknown. This is an international, multicenter, hospital-based, retrospective cohort study that included mBRCA patients diagnosed, between January 2000 and December 2012, with stage I–III invasive early BC at age ≤40 years. From 30 centers worldwide, 1236 young mBRCA BC patients were included. Among 808 and 428 patients with mBRCA1 or mBRCA2, 191 (23.6%) and 356 (83.2%) had HR+tumors, respectively (P