학술논문
Influence of circadian clocks on adaptive immunity and vaccination responses
Document Type
article
Author
Louise Madeleine Ince; Coline Barnoud; Lydia Kay Lutes; Robert Pick; Chen Wang; Flore Sinturel; Chien-Sin Chen; Alba de Juan; Jasmin Weber; Stephan J. Holtkamp; Sophia Martina Hergenhan; Jennifer Geddes-McAlister; Stefan Ebner; Paola Fontannaz; Benjamin Meyer; Maria Vono; Stéphane Jemelin; Charna Dibner; Claire-Anne Siegrist; Felix Meissner; Frederik Graw; Christoph Scheiermann
Source
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2041-1723
62447920
62447920
Abstract
Circadian rhythms have been shown to influence immune responses, but it is unclear whether this influences responses to vaccines. Here the authors show that dendritic cells migrate in a circadian rhythm meaning that interactions with T cells are altered leading to differential vaccine responses.