학술논문
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation
Document Type
article
Author
Zachary A. Hing; Janek S. Walker; Ethan C. Whipp; Lindsey Brinton; Matthew Cannon; Pu Zhang; Steven Sher; Casey B. Cempre; Fiona Brown; Porsha L. Smith; Claudio Agostinelli; Stefano A. Pileri; Jordan N. Skinner; Katie Williams; Hannah Phillips; Jami Shaffer; Larry P. Beaver; Alexander Pan; Kyle Shin; Charles T. Gregory; Gulcin H. Ozer; Selen A. Yilmaz; Bonnie K. Harrington; Amy M. Lehman; Lianbo Yu; Vincenzo Coppola; Pearlly Yan; Peggy Scherle; Min Wang; Philip Pitis; Chaoyi Xu; Kris Vaddi; Selina Chen-Kiang; Jennifer Woyach; James S. Blachly; Lapo Alinari; Yiping Yang; John C. Byrd; Robert A. Baiocchi; Bradley W. Blaser; Rosa Lapalombella
Source
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpression in a CLL mouse model leads to increased risk of transformation, and that targeted PRMT5 inhibition prolongs survival and delays disease development.