학술논문

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Document Type
article
Author
Puya GharahkhaniEric JorgensonPirro HysiAnthony P. KhawajaSarah PendergrassXikun HanJue Sheng OngAlex W. HewittAyellet V. SegrèJohn M. RouhanaAndrew R. HamelRobert P. IgoHelene ChoquetAyub QassimNavya S. JosyulaJessica N. Cooke BaileyPieter W. M. BonnemaijerAdriana IglesiasOwen M. SiggsTerri L. YoungVeronique VitartAlberta A. H. J. ThiadensJuha KarjalainenSteffen UebeRonald B. MellesK. Saidas NairRobert LubenMark SimcoeNishani AmersingheAngela J. CreeRene HohnAlicia PoplawskiLi Jia ChenShi-Song RongTin AungEranga Nishanthie VithanaNEIGHBORHOOD consortiumANZRAG consortiumBiobank Japan projectFinnGen studyUK Biobank Eye and Vision ConsortiumGIGA study groupand Me Research TeamGen TamiyaYukihiro ShigaMasayuki YamamotoToru NakazawaHannah CurrantEwan BirneyXin WangAdam AutonMichelle K. LuptonNicholas G. MartinAdeyinka AshayeOlusola OlawoyeSusan E. WilliamsStephen AkafoMichele RamsayKazuki HashimotoYoichiro KamataniMasato AkiyamaYukihide MomozawaPaul J. FosterPeng T. KhawJames E. MorganNicholas G. StrouthidisPeter KraftJae H. KangChi Pui PangFrancesca PasuttoPaul MitchellAndrew J. LoteryAarno PalotieCornelia van DuijnJonathan L. HainesChris HammondLouis R. PasqualeCaroline C. W. KlaverMichael HauserChiea Chuen KhorDavid A. MackeyMichiaki KuboChing-Yu ChengJamie E. CraigStuart MacGregorJaney L. Wiggs
Source
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Subject
Science
Language
English
ISSN
2041-1723
Abstract
Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.