학술논문
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
Document Type
article
Author
Ladan Khodaparast; Laleh Khodaparast; Rodrigo Gallardo; Nikolaos N. Louros; Emiel Michiels; Reshmi Ramakrishnan; Meine Ramakers; Filip Claes; Lydia Young; Mohammad Shahrooei; Hannah Wilkinson; Matyas Desager; Wubishet Mengistu Tadesse; K. Peter R. Nilsson; Per Hammarström; Abram Aertsen; Sebastien Carpentier; Johan Van Eldere; Frederic Rousseau; Joost Schymkowitz
Source
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell death, which could serve as antibacterial strategy.