학술논문
Cancer associated fibroblast FAK regulates malignant cell metabolism
Document Type
article
Author
Fevzi Demircioglu; Jun Wang; Juliana Candido; Ana S. H. Costa; Pedro Casado; Beatriz de Luxan Delgado; Louise E. Reynolds; Jesus Gomez-Escudero; Emma Newport; Vinothini Rajeeve; Ann-Marie Baker; Marina Roy-Luzarraga; Trevor A. Graham; Julie Foster; Yu Wang; James J. Campbell; Rajinder Singh; Penglie Zhang; Thomas J. Schall; Frances R. Balkwill; Jane Sosabowski; Pedro R. Cutillas; Christian Frezza; Patricia Sancho; Kairbaan Hodivala-Dilke
Source
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencing in CAFs promotes tumourigenesis by the paracrine regulation of cancer cell metabolism.