학술논문
Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Document Type
article
Author
Sangeetha Shyam; Jesús Francisco García-Gavilán; Indira Paz-Graniel; José J. Gaforio; Miguel Ángel Martínez-González; Dolores Corella; J. Alfredo Martínez; Ángel M. Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J. Tinahones; José Lapetra; J. Luís Serra-Majem; Aurora Bueno-Cavanillas; Josep A. Tur; Vicente Martín Sánchez; Xavier Pintó; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Emilio Ros; Fernando Fernandez-Aranda; Stephanie K. Nishi; Oscar Garcia-Regata; Estefania Toledo; Eva M. Asensio; Olga Castañer; Antonio Garcia-Rios; Laura Torres-Collado; Enrique Gómez-Gracia; M. Angeles Zulet; Nuria Goñi Ruiz; Rosa Casas; Naomi Cano-Ibáñez; Lucas Tojal-Sierra; A. M. Gómez-Perez; Jose V. Sorlí; Sergio Cinza-Sanjurjo; Sandra Martín-Peláez; Patricia J. Peña-Orihuela; Alejandro Oncina-Canovas; Rafael Perez-Araluce; María Dolores Zomeño; Alice Chaplin; Miguel Delgado-Rodríguez; Nancy Babio; Montserrat Fitó; Jordi Salas-Salvadó
Source
BMC Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
1741-7015
Abstract
Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).