학술논문
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis
Document Type
article
Author
Kristian W. Pajtler; Yiju Wei; Konstantin Okonechnikov; Patricia B. G. Silva; Mikaella Vouri; Lei Zhang; Sebastian Brabetz; Laura Sieber; Melissa Gulley; Monika Mauermann; Tatjana Wedig; Norman Mack; Yuka Imamura Kawasawa; Tanvi Sharma; Marc Zuckermann; Felipe Andreiuolo; Eric Holland; Kendra Maass; Huiqin Körkel-Qu; Hai-Kun Liu; Felix Sahm; David Capper; Jens Bunt; Linda J. Richards; David T. W. Jones; Andrey Korshunov; Lukas Chavez; Peter Lichter; Mikio Hoshino; Stefan M. Pfister; Marcel Kool; Wei Li; Daisuke Kawauchi
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
The molecular mechanisms driving proliferation in the pediatric brain cancer epdendymoma are poorly understood. Here the authors show that a YAP1- MAMLD1 fusion drives tumor formation in mice and show that the fusion protein can collaborate with the TEAD and NFI transcription factors.